Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement.
نویسندگان
چکیده
In a maca-containing herbal supplement claimed to remedy erectile dysfunction, a new sildenafil analogue was found using adulterant screening with TLC, GC-MS and LC-MS/MS. This compound was isolated by column chromatography and HPLC, and identified by extensive 1D- and 2D-NMR and mass spectral analyses. The structure of this new compound was established as 5-[2-ethoxy-5-(piperazine-1-carbonyl) phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one, and was named desethylcarbodenafil.
منابع مشابه
Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement.
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عنوان ژورنال:
- Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
دوره 33 11 شماره
صفحات -
تاریخ انتشار 2016